Everolimus (Afinitor) Usage Guide: Essential Information for Cancer Patients

Tags: Everolimus Afinitor mTOR inhibitor Kidney cancer PNET

1. Key Characteristics

• Mechanism: Inhibits mTOR pathway to block tumor growth

• Indications:

• Advanced renal cell carcinoma

• Pancreatic neuroendocrine tumors

• TSC-associated tumors

2. Dosage Protocol

• Standard dose: 10mg once daily

• Hepatic impairment: Reduce to 5mg daily

• Administration: With/without food at consistent time

3. Cost Considerations

• Original drug: ~$3,000/month

• Generic alternatives available

• Patient assistance programs exist

4. Adverse Effect Management

• Common: Stomatitis, rash, hyperglycemia

• Serious: Pneumonitis, infections (require immediate care)

5. Clinical Q&A

• Missed dose: Take if <6h late; skip if >6h

• Vaccination: Inactivated vaccines only

• Diet: Avoid grapefruit; monitor sugar intake